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An increased risk of non‐melanoma skin cancer during TNF‐inhibitor treatment in psoriasis patients compared to rheumatoid arthritis patients probably relates to disease‐related factors 下载免费PDF全文
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Consensus on performing skin biopsies,laboratory workup,evaluation of tissue samples and reporting of the results in patients with suspected cutaneous graft‐versus‐host disease 下载免费PDF全文
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M.J. van Geel K. Mul M.E.A. de Jager P.C.M. van de Kerkhof E.M.G.J. de Jong M.M.B. Seyger 《Journal of the European Academy of Dermatology and Venereology》2015,29(3):425-437
In 2008, a systematic review revealed that evidence‐based data on efficacy and safety of treatments in paediatric psoriasis are scarce and with low level of evidence. In recent years, publications on this topic have increased exponentially. To present a systematic, evidence‐based update on the efficacy and safety of systemic treatments in paediatric psoriasis and to provide treatment recommendations, an update of the previous review was performed. PubMed, EMBASE and the Cochrane Controlled Clinical Trial Register were searched between January 2007 and March 2014 for all available literature on efficacy and safety of all systemic treatments in paediatric psoriasis. The levels of evidence were determined on the Oxford Centre for Evidence‐based Medicine Levels of Evidence. The newly retrieved evidence was combined with the evidence available in the former review. Fifty‐two studies were included: 36 from the former review, plus 16 new articles. New evidence on induction therapy was mainly available on fumaric acid esters (FAEs), which are shown to be effective in a subgroup of patients. Long‐term (96 weeks) safety and efficacy data on etanercept were found. Prospective studies are scarce. Most conclusions are formulated on studies with low level of evidence. Of the conventional systemic treatments, methotrexate still has the most evidence albeit in a low number of patients and with a low level of evidence. FAEs seem to be effective in a subgroup of patients, with gastro‐intestinal complaints, flushes and temporary shifts in leucocyte counts and liver enzymes being the main side‐effects. Etanercept has still accumulated most evidence of the available systematic treatments, with a large efficacy and reassuring safety profile in a 96‐week follow‐up. 相似文献
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Surgery under general anaesthesia in severe hidradenitis suppurativa: a study of 363 primary operations in 113 patients 下载免费PDF全文
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Evidence‐ and consensus‐based (S3) Guidelines for the Treatment of Actinic Keratosis – International League of Dermatological Societies in cooperation with the European Dermatology Forum – Short version 下载免费PDF全文
R.N. Werner E. Stockfleth S.M. Connolly O. Correia R. Erdmann P. Foley A.K. Gupta A. Jacobs H. Kerl H.W. Lim G. Martin M. Paquet D.M. Pariser S. Rosumeck H.‐J. Röwert‐Huber A. Sahota O.P. Sangueza S. Shumack B. Sporbeck N.A. Swanson L. Torezan A. Nast 《Journal of the European Academy of Dermatology and Venereology》2015,29(11):2069-2079